Catalog Number - 85118-15P-2

The 85118‑15P‑2 Cogent RP C18 ABX™ UHPLC Column is engineered for maximum‑resolution separations in low‑flow LC‑MS workflows, delivering exceptional efficiency and stability across a wide pH range (2–12).

Built with bulky end‑capping and high‑purity silica, this column minimizes unwanted interactions, improving peak shape and reproducibility for acidic, basic, and polar analytes, especially those with extreme pKa values.

✅ Ideal as a USP L1 alternate for methods involving strong acids or bases

150 mm Length – Maximum Resolution for LC‑MS Applications

• Highest resolving power in the 2.1 mm ABX column range

• Maximizes peak capacity for complex mixtures

• Ideal for closely related compounds and difficult separations

• Preferred for final method optimization and high‑resolution LC‑MS workflows

✅ Selected when maximum separation performance is required beyond 50 mm and 100 mm columns

2.1 mm ID – LC‑MS / Low‑Flow Optimization

• Designed for UHPLC and LC‑MS systems

• Enhances mass spectrometry sensitivity via reduced solvent flow

Typical Flow Rate Range

• ~0.2–0.3 mL/min

✅ Requires UHPLC systems capable of precise low‑flow delivery

1.8 µm Particle – Maximum Efficiency & Peak Capacity

• Provides ultra‑high efficiency and superior resolution

• Delivers sharper peaks compared to larger particles

• Enhances separation of complex and trace‑level analytes

✅ Ideal for advanced LC‑MS and UHPLC analytical workflows

⚠️ Higher backpressure → UHPLC system required

Wide pH Stability (pH 2–12) – Extreme Method Capability

• Designed for acidic and basic mobile phases

• Suitable for:

  • Strong acids

  • Strong bases

• Maintains performance under aggressive method conditions

✅ Enables method flexibility beyond standard C18 columns

Why Choose RP C18 ABX™ Columns

Extreme pH Ruggedness

• Stable across full pH spectrum (2–12)

• Ideal for challenging analytes and harsh conditions

Improved Peak Shape for Acids & Bases

• Advanced end‑capping reduces secondary interactions

• Enhances reproducibility and accuracy

High‑Efficiency Method Development

• Faster runs reduce solvent consumption and cost

• Enables higher throughput and productivity

✅ Excellent for high‑resolution LC‑MS method development and validation

System & Sample Considerations

• ⚠️ Requires UHPLC system capable of high pressure operation

• Recommended sample preparation:

  • 👉 Use 0.2 µm syringe filters for proper sample preparation before injection

✅ Helps:

• Prevent column clogging

• Maintain performance and column lifetime

Typical Applications

• LC‑MS and UHPLC analysis

• Acidic and basic compound separations

• Pharmaceutical method development

• Stability‑indicating methods

• Peptide and polar compound analysis

• Complex mixture resolution at extreme pH

Important Usage Notes

• Designed exclusively for UHPLC / LC‑MS workflows

• Requires low‑flow capability (~0.2–0.3 mL/min)

• Best suited for extreme pH mobile phases (pH 2–12)

• Monitor system pressure to ensure safe and stable operation